Ligand and GSK Enter World Collaboration and License Agreement Leveraging Icagen’s Discovery Engineering to Focus on Neurological Diseases

“We are extremely delighted to husband or wife with a world wide pharmaceutical firm like

“We are extremely delighted to husband or wife with a world wide pharmaceutical firm like GSK with an ambitious innovation agenda,” stated Matt Foehr, President and COO of Ligand. “This arrangement suits perfectly in just the Ligand tactic to create and leverage partnerships with market leaders as they entry our systems and abilities for their drug-discovery requirements. GSK has also acknowledged that terrific tips occur from interactions like this just one and they have a heritage of efficiently performing with other folks to access innovation and provide up coming-era transformational medicines.”

“Central to GSK’s innovation agenda is operating with chopping-edge associates to help us create genetically-validated, transformational medications in methods that are faster and much more successful,” stated John Lepore, Senior Vice President, Analysis, GSK. “Ligand’s exceptional product systems and depth of abilities will empower our team to progress this drug-discovery system with a larger likelihood of accomplishment and may well aid supply a new treatment method option for individuals struggling from neurological disorder.”

Beneath the conditions of the collaboration and license settlement, Ligand will obtain an upfront payment of $7 million. Ligand could get extra progress, regulatory and commercialization milestone payments, conditional on conference those milestones, of up to $154.5 million. Ligand will acquire tiered royalties on net profits of any drug from the collaboration that is commercialized by GSK.

Ligand will be accountable for most preclinical functions up to lead optimization, with Ligand and GSK collaborating to identify candidates for entry into IND-enabling scientific tests. GSK has the special choice to license any recognized inhibitors and will be dependable for the further improvement and commercialization of any drug candidates discovered via the collaboration. Ligand obtained Icagen in April 2020, introducing enabling systems to its small business presenting that will assistance this collaborative drug-discovery application.

About Icagen Engineering System

The Icagen Technology System is focused largely on ion channel and transporter novel drug discovery. Ion channels and transporters are key factors in a huge variety of organic processes that entail immediate variations in cells and have wide therapeutic applicability including cancer, metabolic ailment, soreness, neurological disorders, infectious health conditions and other people. The Icagen Technologies System leverages proprietary knowledge in the mixture of biological assays, medicinal chemistry, and in silico and computational chemistry programs. Associates in the pharmaceutical sector leverage our platform to build very first-in-course therapies for people in need, generally underneath preparations in which we operate closely by way of the time of scientific candidate collection, with our partners dependable for clinical enhancement and commercialization. For a lot more information and facts, you should stop by www.ligand.com.

About Ligand Prescription drugs

Ligand is a income-making biopharmaceutical enterprise concentrated on acquiring or acquiring technologies that help pharmaceutical organizations find and develop medications. Ligand’s business product results in benefit for stockholders by giving a diversified portfolio of biotech and pharmaceutical products revenue streams that are supported by an economical and low corporate price composition. Ligand’s intention is to present traders an possibility to participate in the assure of the biotech field in a lucrative, diversified and lessen-risk small business than a normal biotech company. Ligand’s enterprise design is based on accomplishing what Ligand does very best: drug discovery, early-phase drug advancement, product or service reformulation and partnering. Ligand associates with other pharmaceutical corporations to leverage what they do very best (late-phase improvement, regulatory management and commercialization) to ultimately produce our revenue. Ligand’s OmniAb® technology platform is a patent-shielded transgenic animal system applied in the discovery of absolutely human mono- and bispecific therapeutic antibodies. The Captisol® system engineering is a patent-secured, chemically modified cyclodextrin with a composition developed to improve the solubility and security of medicine. Ligand’s Protein Expression Technological know-how® is a sturdy, validated, price-powerful and scalable tactic to recombinant protein output, and is primarily effectively-suited for elaborate, substantial-scale protein output that simply cannot be produced by extra common systems. Ab Initio™ engineering and expert services for the design and preparing of custom-made antigens enable the effective discovery of therapeutic antibodies in opposition to tough-to-obtain cellular targets. Ligand has founded several alliances, licenses and other enterprise relationships with the world’s primary pharmaceutical corporations like Amgen, Merck, Pfizer, Roche, Sanofi, Janssen, Takeda, Gilead Sciences, GSK and Baxter Global. For extra information and facts, please go to www.ligand.com.

Observe Ligand on Twitter @Ligand_LGND.

Ahead-Hunting Statements

This information launch consists of forward-wanting statements by Ligand that contain risks and uncertainties and replicate Ligand’s judgment as of the date of this release. Words and phrases this sort of as “plans,” “believes,” “expects,” “anticipates,” and “will,” and identical expressions, are supposed to identify forward-wanting statements. These ahead-searching statements include things like, without limitation, statements relating to the likely gains of the Ligand Group/GSK collaboration settlement software. Actual functions or effects could differ from Ligand’s expectations owing to dangers and uncertainties inherent in Ligand’s enterprise, such as, devoid of limitation: there can be no assurance that the GSK software with Ligand will be in a position to correctly identify any fascinating drug candidates or that any drug candidates made in such applications would be clinically or commercially effective, all of which may outcome in the probable license alternative work out cost, milestone payments and royalties not staying acquired Ligand may not receive expected revenue from royalties, Captisol profits, deal and service profits the COVID-19 pandemic has disrupted Ligand’s and its partners’ enterprise, including delaying production, pre-scientific studies and scientific trials and merchandise revenue, and impairing global economic exercise, all of which could materially and adversely affect Ligand’s results of operations and fiscal ailment productive COVID-19 vaccines could limit the industry for Captisol-enabled remdesivir Ligand and its companions may well not be equipped to well timed or properly advance any merchandise(s) in its inside or partnered pipeline Ligand may perhaps not accomplish its advice for 2020 improvement of merchandise candidates by Ligand associates may not be effective Ligand could not be ready to develop potential revenues and dollars flows by building modern therapeutics benefits of any scientific study might not be well timed, favorable or confirmed by afterwards reports items less than improvement by Ligand or its companions could not get regulatory acceptance there may perhaps not be a market for the product(s) even if effectively produced and authorised Ligand or its companions may not be ready to shield their intellectual home and patents masking sure products and technologies may be challenged or invalidated Ligand’s companions may possibly terminate any of its agreements or growth or commercialization of any of its products and solutions Ligand might not crank out anticipated revenues beneath its present license agreements Ligand and its partners may encounter delays in the commencement, enrollment, completion or evaluation of medical testing for its item candidates, or major issues regarding the adequacy of its scientific trial designs or the execution of its medical trials, which could outcome in amplified costs and delays, or limit Ligand’s potential to attain regulatory acceptance surprising adverse side outcomes or inadequate therapeutic efficacy of Ligand’s merchandise(s) could hold off or avert regulatory approval or commercialization Ligand may not be able to correctly put into action its strategic advancement program and carry on the advancement of its proprietary applications and ongoing or long term litigation could expose Ligand to major liabilities and have a material adverse influence on the business. The failure to satisfy expectations with respect to any of the foregoing matters may well lessen Ligand’s stock selling price. Extra information relating to these and other threat things influencing Ligand can be identified in prior press releases obtainable at www.ligand.com as perfectly as in Ligand’s public periodic filings with the Securities and Trade Fee offered at www.sec.gov. Ligand disclaims any intent or obligation to update these ahead-seeking statements beyond the day of this launch. This warning is manufactured under the safe and sound harbor provisions of the Private Securities Litigation Reform Act of 1995.