Pharmacological and clinical application of heparin progress: An critical drug for modern day medicine

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Biomed Pharmacother. 2021 Apr 10139:111561. doi: 10.1016/j.biopha.2021.111561. On-line ahead of print.


Heparin is the earliest and most commonly used anticoagulant and antithrombotic drug that is even now utilized in a variety of clinical indications. Due to the fact it was found out in 1916, soon after a lot more than a century of repeated exploration, heparin has not been replaced by other prescription drugs, but a good progress has been manufactured in its simple research and medical application. Apart from anticoagulant and antithrombotic results, heparin also has antitumor, anti-inflammatory, antiviral, and other pharmacological functions. It is greatly employed clinically in cardiovascular and cerebrovascular health conditions, lung disorders, kidney health conditions, most cancers, and many others., as the initial anticoagulant medicine in COVID-19 exerts anticoagulant, anti-inflammatory and antiviral effects. At the exact same time, even so, it also qualified prospects to a good deal of adverse reactions, this sort of as bleeding, thrombocytopenia, elevated transaminase, allergic reactions, and some others. This short article comprehensively opinions the present day exploration progress of heparin compounds discusses the framework, preparing, and adverse reactions of heparin emphasizes the pharmacological activity and scientific software of heparin reveals the doable mechanism of the therapeutic impact of heparin in linked scientific purposes gives proof assistance for the scientific software of heparin and hints on the significance of checking out the broader application fields of heparin.

PMID:33848775 | DOI:10.1016/j.biopha.2021.111561